Impacts of dietary fat on multi tissue gene expression in the desert-adapted cactus mouse.

ABSTRACT: Understanding the relationship between dietary fat and physiological responses is crucial in species adapted to arid environments where water scarcity is common. In this study, we present a comprehensive exploration of gene expression across five tissues (kidney, liver, lung, gastrointestinal tract and hypothalamus) and 17 phenotypic measurements, investigating the effects of dietary fat in the desert-adapted cactus mouse (Peromyscus eremicus). We show impacts on immune function, circadian gene regulation and mitochondrial function for mice fed a lower-fat diet compared with mice fed a higher-fat diet. In arid environments with severe water scarcity, even subtle changes in organismal health and water balance can affect physical performance, potentially impacting survival and reproductive s

SUBMITTER: Blumstein DM 

PROVIDER: S-EPMC11698062 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature