A systematic review and meta-analysis of the traumatogenic phenotype hypothesis of psychosis.

ABSTRACT:

Background

Developmental trauma increases psychosis risk and is associated with poor prognosis. It has been proposed that psychosis in survivors of developmental trauma gives rise to a distinct 'traumatogenic' phenotype.

Aims

Given the implications for personalised treatment, we sought to explore the traumatogenic psychosis phenotype hypothesis in a systematic review and meta-analysis of studies comparing psychotic presentations between adults with and without developmental trauma histories.

Method

We registered the systematic review on PROSPERO (CRD42019131245) and systematically searched EMBASE, Medline and PsycINFO. The outcomes of interests were quantitative and qualitative comparisons in psychotic symptom expression (positive, negative, cognitive) and other domai

SUBMITTER: Onyeama F 

PROVIDER: S-EPMC11698141 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature