Clinical and neurocognitive profiles of a combined clinical high risk for psychosis and clinical control sample: latent class analysis.

ABSTRACT:

Background

The clinical high-risk (CHR) state for psychosis demonstrates considerable clinical heterogeneity, presenting challenges for clinicians and researchers alike. Basic symptoms, to date, have largely been ignored in explorations of clinical profiles.

Aims

We examined clinical profiles by using a broader spectrum of CHR symptoms, including not only (attenuated) psychotic, but also basic symptoms.

Method

Patients (N = 875) of specialised early intervention centres for psychosis in Germany and Switzerland were assessed with the Schizophrenia Proneness Instruments and the Structured Interview for Psychosis-Risk Syndromes. Latent class analysis was applied to CHR symptoms to identify clinical profiles. Additionally, demographics, other symptoms, current non-

SUBMITTER: Stuble M 

PROVIDER: S-EPMC11698148 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature