Behavioural and neuronal substrates of serious game-based computerised cognitive training in cognitive decline: randomised controlled trial.

ABSTRACT:

Background

Investigations of computerised cognitive training (CCT) show heterogeneous results in slowing age-related cognitive decline.

Aims

To comprehensively evaluate the effectiveness of serious games-based CCT, integrating control conditions, neurophysiological and blood-based biomarkers, and subjective measures.

Method

In this bi-centric randomised controlled trial with parallel groups, 160 participants (mean age 71.3 years) with cognitive impairment ranging from subjective decline to mild cognitive impairment, were pseudo-randomised to three arms: an intervention group receiving CCT immediately, an active control (watching documentaries) and a waitlist condition, which both started the CCT intervention after the control period. Both active arms entailed a 3-mont

SUBMITTER: Brill E 

PROVIDER: S-EPMC11698156 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature