Trends in childhood cancer: Incidence and survival analysis over 45 years of SEER data.

ABSTRACT:

Background

The SEER Registry contains U.S. cancer statistics. To assess trends in incidence and survival and the impact of demographic factors among pediatric patients with cancer, we assessed nearly 5 decades (1975-2019) of data.

Methods

All patients below the age of 20 with histology-confirmed malignancy were studied. Kaplan-Meier survival curves were generated to evaluate survival trends across treatment periods and ICCC classes. JoinPoint analysis was conducted to identify changes in incidence and survival.

Results

The incidence of childhood cancer increased from 14.23 cases per 100,000 children in 1975-1979 to 18.89 in 2010-2019, with an average annual percent change of 0.73. This rise was more pronounced in several cancers, including leukemias, lymphomas, brain

SUBMITTER: Sultan I 

PROVIDER: S-EPMC11698462 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature