The Statistics of Parametrized Syncmers in a Simple Mutation Process Without Spurious Matches.

ABSTRACT: Introduction: Often, bioinformatics uses summary sketches to analyze next-generation sequencing data, but most sketches are not well understood statistically. Under a simple mutation model, Blanca et al. analyzed complete sketches, that is, the complete set of unassembled k-mers, from two closely related sequences. The analysis extracted a point mutation parameter θ quantifying the evolutionary distance between the two sequences. Methods: We extend the results of Blanca et al. for complete sketches to parametrized syncmer sketches with downsampling. A syncmer sketch can sample k-mers much more sparsely than a complete sketch. Consider the following simple mutation model disallowing insertions or deletions. Consider a reference sequence A (e.

SUBMITTER: Spouge JL 

PROVIDER: S-EPMC11698668 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature