Distinct immune signatures for predicting the immunotherapy efficacy of esophageal squamous cell carcinoma or adenocarcinoma.

ABSTRACT: Esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC) are distinct histological subtypes of esophageal cancer. The tumor microenvironment of each subtype significantly influences the efficacy of immunotherapy. However, the characteristics of the tumor microenvironments of both subtypes, as well as their specific impacts on immunotherapy outcomes, still require further elucidation. Through the integration of gene expression profiles from ESCC and EAC obtained from The Cancer Genome Atlas database, alongside tumor tissues derived from Chinese patients, we identified TNFSF10, CXCL10, IL17RB, and CSF2 as pivotal immune molecules with significant prognostic implications. Elevated expression levels of TNFSF10 correlated with adverse outcomes in individuals diagnosed with

SUBMITTER: Wu P 

PROVIDER: S-EPMC11698706 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature