In vitro and In silico investigation deciphering novel antifungal activity of endophyte Bacillus velezensis CBMB205 against Fusarium oxysporum.

ABSTRACT: Endophytes from medicinal plants are potential biocontrol agents against Fusarium oxysporum f. sp. cubense (Foc), which is the causative fungus of banana wilt disease. In the present study, the endophytic bacterium was isolated from Globba racemosa and their antagonistic activities against Foc were studied, and the probable molecular mechanism of antagonism was predicted by molecular docking studies. The 16SrRNA sequencing confirmed the endophytic isolate to be Bacillus velezensis CBMB205 (EG2). The antagonistic activities of the isolates by distortion of fungal hyphae were illustrated in SEM. The probable metabolites present in endophytic isolate were identified by FTIR, suggesting the presence of C-H, CH3 and O-H groups. Two major metabolites such as β-amyrin and dihydroxy octadecenoic a

SUBMITTER: R V 

PROVIDER: S-EPMC11698993 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature