Prognostic immune markers in esophageal cancer patients managed with trimodal therapy.

ABSTRACT:

Background

Esophageal cancer (ESC) is an aggressive disease which often presents at an advanced stage. Despite trimodal therapy, 40-50% patients can develop metastatic disease by 18 months. Identification of patients at risk for metastatic spread is challenging with need for improved prognostication. We investigated whether the immune landscape of pretreatment tissue was associated with relapse in ESC patients.

Methods

Between April 2010 and October 2018, we identified 25 patients who had undergone trimodal therapy for ESC and had pretreatment biopsies suitable for analyses. We performed high-throughput multispectral immunofluorescence (mIF) analysis on formalin-fixed paraffin embedded biopsy samples. Analysis of 27 unique populations via immune and exhaustion mIF panels was

SUBMITTER: Farrugia MK 

PROVIDER: S-EPMC11698998 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature