Organocatalysed synthesis of <i>N</i>-(4-oxo-2-phenyl-1,2-dihydroquinazolin-3(4<i>H</i>)-yl)isonicotinamide: computational, electrochemical, drug-likeness and antimicrobial studies.

ABSTRACT: We have developed novel and sustainable homogeneous catalysts employing Glutamic acid (Glu) as a biodegradable and eco-friendly organocatalyst for the synthesis of N-(4-oxo-2-phenyl-1,2-dihydroquinazolin-3(4H)-yl)isonicotinamide derivatives (5a-l) via multicomponent reactions (MCRs) of isatoic anhydride, isoniazid and heteroaromatic/aromatic aldehyde in ethanol on oil bath stirring at 60 °C. Selected final product homogeneity was examined by various spectroscopic techniques such as ¹³C-, ¹H- NMR, FT-IR and LC-MS. For the first time, herein investigated electrochemical behavior of selected derivatives (5c, 5h-l) using cyclic voltammetry method. The results of this investigation indicated compounds 5i, 5h and 5l ex

SUBMITTER: Mane RR 

PROVIDER: S-EPMC11699011 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature