Identification of immune suppressor candidates utilizing comparative transcriptional profiling in histiocytic sarcoma.

ABSTRACT: Histiocytic sarcoma (HS) is a rare yet lethal malignancy with no established standard of care therapies. A lack of pre-clinical models limits our understanding of HS pathogenesis and identification of therapeutic targets. Canine HS shares multiple clinical and genetic similarities with human HS, supporting its use as a unique translational model. Prior studies have investigated the immunogenicity of HS. Although increased tumor infiltrating lymphocyte (TIL) density is associated with favorable outcomes in canine HS, virtually all canine patients eventually succumb to progressive disease consistent with ultimate failure of anti-tumor immunity. To investigate potential regulators of the immune tumor microenvironment (TME), we undertook a comparative transcriptional approach of three long-liv

SUBMITTER: Lenz JA 

PROVIDER: S-EPMC11699166 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature