Clustering of > 145,000 symptom logs reveals distinct pre, peri, and menopausal phenotypes.

ABSTRACT: The transition to menopause is associated with disappearance of menstrual cycle symptoms and emergence of vasomotor symptoms. Although menopausal women report a variety of additional symptoms, it remains unclear which emerge prior to menopause, which occur in predictable clusters, how clusters change across the menopausal transition, or if distinct phenotypes are present within each life stage. We present an analysis of symptoms in premenopausal to menopausal women using the MenoLife app, which includes 4789 individuals (23% premenopausal, 29% perimenopausal, 48% menopausal) and 147,501 symptom logs (19% premenopausal, 39% perimenopausal, 42% menopausal). Clusters generated from logs of 45 different symptoms were assessed for similarities across methods: hierarchical clustering analysis (H

SUBMITTER: Aras SG 

PROVIDER: S-EPMC11699220 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature