Mental Disorders Among Offspring Prenatally Exposed to Systemic Glucocorticoids.

ABSTRACT:

Importance

Current evidence of the association between prenatal exposure to glucocorticoids and long-term mental disorders is scarce and has limitations.

Objective

To investigate the association between prenatal exposure to systemic glucocorticoids and mental disorders in offspring at the age of 15 years, comparing exposed vs unexposed offspring born to mothers with the same underlying disease (risk of preterm delivery and autoimmune or inflammatory disorders).

Design, setting, and participants

This nationwide population-based cohort study used data from registries in Denmark with follow-up until December 31, 2018. Participants included all Danish infants born alive from 1996 to 2016. Analyses were performed from January to December 2023.

Exposures

Prenatal exp

SUBMITTER: Laugesen K 

PROVIDER: S-EPMC11699534 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature