Zinc finger protein 593 promotes breast cancer development by ensuring DNA damage repair and cell-cycle progression.

ABSTRACT: Breast cancer, a common malignancy and top cause of female cancer deaths globally, urgently requires new biomarkers and insights into its progression and chemoresistance. In this study, we identify ZNF593, a member of the zinc finger protein family, as an understudied oncogene in breast cancer. ZNF593 is significantly upregulated in breast cancer tissues compared to adjacent normal tissues, which is linked to poor prognosis and advanced clinicopathological features. In vitro experiments demonstrate that ZNF593 enhances the proliferation and migration capabilities of breast cancer cells. Comprehensive analyses reveal that ZNF593 is associated with DNA damage repair, cell-cycle regulation, and immunity-related pathways. Mechanistically, ZNF593 protects DNA repair and influences sensit

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11699609 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature