Tumor burden with AFP improves survival prediction for TACE-treated patients with HCC: An international observational study^☆.

ABSTRACT:

Background & aims

Current prognostic models for patients with hepatocellular carcinoma (HCC) undergoing transarterial chemoembolization (TACE) are not extensively validated and widely accepted. We aimed to develop and validate a continuous model incorporating tumor burden and biology for individual survival prediction and risk stratification.

Methods

Overall, 4,377 treatment-naive candidates for whom TACE was recommended, from 39 centers in five countries, were enrolled and divided into training, internal validation, and two external validation datasets. The novel model was developed using a Cox multivariable regression analysis and compared with our original 6-and-12 model (the largest tumor size [ts, centimetres] + tumor number [tn]) and other available models in terms of

SUBMITTER: Xia D 

PROVIDER: S-EPMC11699734 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature