Mapping the neural substrate of high dual-task gait cost in older adults across the cognitive spectrum.

ABSTRACT: The dual task cost of gait (DTC) is an accessible and cost-effective test that can help identify individuals with cognitive decline and dementia. However, its neural substrate has not been widely described. This study aims to investigate the neural substrate of the high DTC in older adults across the spectrum of cognitive decline. A total of 336 individuals from the GAIT study cohort were analyzed, including cognitively healthy (N = 122, 71 ± 3.6 years), those with mild cognitive impairment (N = 168, 71 ± 5.3 years), and those with dementia (N = 46, 80 ± 5.7 years). A DTC of 20% or greater was considered to indicate a high level of slowing down while performing successively two verbal tasks (counting backwards task by ones and naming animals). Voxel-based morphometry was employed to invest

SUBMITTER: Ali P 

PROVIDER: S-EPMC11700055 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature