Noncoding RNA Terc-53 and hyaluronan receptor Hmmr regulate aging in mice.

ABSTRACT: One of the basic questions in the aging field is whether there is a fundamental difference between the aging of lower invertebrates and mammals. A major difference between the lower invertebrates and mammals is the abundancy of noncoding RNAs, most of which are not conserved. We have previously identified a noncoding RNA Terc-53 that is derived from the RNA component of telomerase Terc. To study its physiological functions, we generated two transgenic mouse models overexpressing the RNA in wild-type and early-aging Terc-/- backgrounds. Terc-53 mice showed age-related cognition decline and shortened life span, even though no developmental defects or physiological abnormality at an early age was observed, indicating its involvement in normal aging of mammals. Subsequent mechanistic study ide

SUBMITTER: Wu S 

PROVIDER: S-EPMC11700592 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature