Characterization of undifferentiated carcinomas of the pancreas with and without osteoclast-like giant cells.

ABSTRACT:

Background

Undifferentiated carcinoma (UC) is a rare subtype of pancreatic cancer distinguished from UC with osteoclast-like giant cells (UC-OGC) in 2019, affecting interpretation of literature that does not distinguish these subtypes. We sought to identify translationally relevant differences between these 2 variants and compared with pancreatic ductal adenocarcinoma.

Methods

We characterized clinical and multiomic differences between UC (n = 32) and UC-OGC (n = 15) using DNA sequencing, RNA sequencing, and multiplex immunofluorescence and compared these findings with pancreatic ductal adenocarcinoma.

Results

Characteristics at diagnosis were similar between UC and UC-OGC, though the latter was more resectable (P = .009). Across all stages, median overall survival wa

SUBMITTER: Mills JN 

PROVIDER: S-EPMC11700618 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature