Biomarker and neuropsychological correlates of the N400 event-related potential in Alzheimer's disease.

ABSTRACT:

Objective

The current study sought to characterize the relationship of the N400 (N4) effect event-related potential to Alzheimer's disease (AD) biomarkers and broader cognition in older adults on the late-life cognitive continuum.

Method

Participants who were cognitively intact (n = 43), or had amnestic mild cognitive impairment (MCI; n = 19), or mild AD (n = 12), completed a word-pair judgement task during concurrent EEG recording to elicit the N400. The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and biomarker data (PET-imaged beta-amyloid (aβ) deposition, apolipoprotein-E ε4 (APOE4) allele status, hippocampal volumes) were collected as part of a larger study.

Results

The AD group had slower response times and poorer accuracy on the wo

SUBMITTER: Geiger AR 

PROVIDER: S-EPMC11700776 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature