More micrometastases, more recurrence? The role of qPCR of PSA mRNA in lymph nodes during prostatectomy.

ABSTRACT:

Background and objectives

Radical prostatectomy is a standard treatment for prostate cancer, yet about 30% of patients experience rising biochemical markers within a decade post-surgery. Pelvic lymph node sampling during prostatectomy assesses potential lymph node metastases, but standard histological assessments, which typically examine only 2-3 tissue sections, often miss occult metastases. This study assesses the effectiveness of qPCR in detecting PSA coding KLK3 mRNA for identifying lymph node metastases post-prostatectomy and explores the correlation between PSA-mRNA and biochemical recurrence.

Methods

A cohort of 157 patients who underwent radical prostatectomy with lymphadenectomy were examine. On average, 24.7 lymph nodes were removed per patient. Among them, 108 pat

SUBMITTER: Troidl J 

PROVIDER: S-EPMC11700908 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature