Regulator of G protein signaling-1 facilitates ovarian cancer development by modulating NF-kB signal pathway.

ABSTRACT: Regulator of G protein signaling 1 (RGS1) is known to be highly expressed in various tumors, but its specific effects and regulatory mechanism in ovarian cancer (OC) progression are not well understood. To delve into the tumor biology, a predictive risk model for OC was developed, incorporating RGS1, PRKG2, CD24, and ABCB1, with RGS1 exhibiting the strongest correlation. The model's reliability and validity were confirmed through Kaplan-Meier analysis, receiver operating characteristic (ROC) curve, and principal component analysis (PCA). The risk score was validated as an independent indicator of overall survival, and a nomogram model was created to predict overall survival. Moreover, RGS1 expression was found to be up-regulated and associated with a poor prognosis in OC. Functional studie

SUBMITTER: Shengnan L 

PROVIDER: S-EPMC11701083 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature