Wooden breast myopathy is characterized by satellite cell dysfunction and syndecan-4 shedding.

ABSTRACT:

Introduction

Skeletal muscle satellite cells (MuSCs or stem cells) play a crucial role in muscle development, maintenance, and regeneration, supporting both hypertrophy and regenerative myogenesis. Syndecans (SDCs) act as communication bridges within the muscle microenvironment, regulating interactions with extracellular matrix components and contributing significantly to tissue repair and inflammation. Specifically, syndecan-4 (SDC4) is involved in muscle regeneration at multiple stages.

Methods

This study delves into the emerging challenge of wooden breast (WB) myopathy and its connection with SDC4. Our hypothesis proposes that disruptions in MuSC dynamics through SDC4 contribute to the increased incidence of breast myopathies observed in growing broilers. To test our hypo

SUBMITTER: Pejskova L 

PROVIDER: S-EPMC11701147 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature