Overcoming tet(X)-harboring tigecycline resistance: a study on the efficacy of tigecycline-apramycin combinations.

ABSTRACT:

Introduction

The emergence of the wide variety of novel tigecycline resistance tet(X) variants, including tet(X3), tet(X4), tet(X5), and tet(X6), has raised a serious threat to global public health and posed a significant challenge to the clinical treatment of multidrug-resistant bacterial infections.

Methods

In this study, we evaluated the synergism of tigecycline combining with other antibiotics as a means of overcoming the tet(X)-mediated resistance in Acinetobacter spp. Antibiotic synergistic efficacy was evaluated through in vitro chequerboard experiments, time-kill assays and dose-response curves. The in vivo synergistic effect of the combination was confirmed in a mouse model of thigh with neutrophilic gra

SUBMITTER: Liu J 

PROVIDER: S-EPMC11701230 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature