Development and internal validation of a clinical and genetic risk score for rheumatoid arthritis-associated interstitial lung disease.

ABSTRACT:

Objective

Although clinical and genetic risk factors have been identified for rheumatoid arthritis-associated interstitial lung disease (RA-ILD), there are no current tools allowing for risk stratification. We sought to develop and validate an ILD risk model in a large, multicentre, prospective RA cohort.

Methods

Participants in the Veterans Affairs RA (VARA) registry were genotyped for 12 single nucleotide polymorphisms (SNPs) associated with idiopathic pulmonary fibrosis. ILD was validated through systematic record review. A genetic risk score (GRS) was computed from minor alleles weighted by effect size with ILD, using backward selection. The GRS was combined with clinical risk factors within a logistic regression model. Internal validation was completed using bootstrappi

SUBMITTER: Wheeler AM 

PROVIDER: S-EPMC11701303 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature