Rheumatoid arthritis, quantitative parenchymal lung features and mortality among smokers.

ABSTRACT:

Objectives

There have been limited investigations of the prevalence and mortality impact of quantitative CT (QCT) parenchymal lung features in RA. We examined the cross-sectional prevalence and mortality associations of QCT features, comparing RA and non-RA participants.

Methods

We identified participants with and without RA in COPDGene, a multicentre cohort study of current or former smokers. Using a k-nearest neighbour quantifier, high resolution CT chest scans were scored for percentage of normal lung, interstitial changes and emphysema. We examined associations between QCT features and RA using multivariable linear regression. After dichotomizing participants at the 75th percentile for each QCT feature among non-RA participants, we investigated mortality associations by

SUBMITTER: McDermott GC 

PROVIDER: S-EPMC11701304 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature