Impact of different treatments for chronic pain on cognitive function: A systematic review.

ABSTRACT:

Introduction

Experimental evidence supports the hypothesis of reciprocal influence between neural systems involved in cognition and central pain processing circuits. Furthermore, studies have demonstrated bidirectional communication between central pain processing areas and the immune system, leading to changes in behaviour, sensory perception, mood, and cognition. However, the academic community has not yet reached a consensus on whether effective analgesic interventions can mitigate or reverse cognitive deterioration.

Methods

This systematic review evaluated the effectiveness of various therapeutic interventions in improving cognitive functions (primary outcome) and altering the profile of immunological markers (secondary outcome) in chronic pain patients. The review was l

SUBMITTER: Brennecke AB 

PROVIDER: S-EPMC11701906 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature