CAST Regimen for GvHD Prophylaxis: A CIBMTR Propensity Score-Matched Analysis.

ABSTRACT: Previously, we reported excellent results with the combination of post-transplant cyclophosphamide (PTCy), abatacept, and a short course of tacrolimus (CAST) for the prevention of graft-versus-host disease (GvHD) following peripheral blood haploidentical transplantation. To further substantiate these results, we performed a propensity score-matched analysis. Patients enrolled in the CAST trial were matched with patients from a contemporaneous cohort from the Center for International Blood and Marrow Transplant Research database who received PTCy, tacrolimus, and mycophenolate mofetil, using nearest neighbor propensity score matching. An excellent balance between pairs was achieved as measured by the density distribution and standardized differences of covariates (median 0.09). The rates of

SUBMITTER: Al-Homsi AS 

PROVIDER: S-EPMC11701941 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature