Genome scan reveals several loci associated with torus palatinus.

ABSTRACT:

Objective

Torus Palatinus (TP) is a common trait with an unclear aetiology. Although prior studies suggest a hereditary component, the genetic factors that influence TP risk remain unknown. The purpose of this study is to identify genetic variants associated with TP.

Materials and methods

We assessed the TP status of 829 individuals from various ancestral backgrounds using 3D palate scans. We then carried out a genome-wide association study (GWAS) to identify common variants associated with TP. We also performed gene-based tests across the exome to investigate the role of low-frequency coding variants.

Results

Our GWAS did not identify any genome-wide significant signals but identified suggestive associations including hits on chromosomes 2, 5 and 17 with p-values les

SUBMITTER: Lee MK 

PROVIDER: S-EPMC11701952 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature