Pathogenicity of tick-derived lymphocytic choriomeningitis virus in BALB/c mice.

ABSTRACT:

Background

Lymphocytic choriomeningitis virus (LCMV) is a zoonotic pathogen primarily transmitted by rodents. Recently, LCMV has been detected in ticks from northeastern China; however, the pathogenicity of this virus in murine models remains to be elucidated.

Results

Here, we examined the tick-derived LCMV strain JX14 by inoculating BALB/c mice with 3.5 × 10⁵ pfu of virus. The mice infected with LCMV displayed clinical manifestations including unkempt fur, anorexia, depression, and oliguria, which subsequently resolved by 10 days post infection (dpi) leading to survival of the infection. During the early phase of infection, low viral titers were detected in throat and anal swabs. The excreted virions demonstrated proliferation in Vero cells and were capable of in

SUBMITTER: Liu Z 

PROVIDER: S-EPMC11702202 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature