Repotrectinib in <i>ROS1</i> Fusion-Positive Non-Small-Cell Lung Cancer.

ABSTRACT:

Background

The early-generation ROS1 tyrosine kinase inhibitors (TKIs) that are approved for the treatment of ROS1 fusion-positive non-small-cell lung cancer (NSCLC) have antitumor activity, but resistance develops in tumors, and intracranial activity is suboptimal. Repotrectinib is a next-generation ROS1 TKI with preclinical activity against ROS1 fusion-positive cancers, including those with resistance mutations such as ROS1 G2032R.

Methods

In this registrational phase 1-2 trial, we assessed the efficacy and safety of repotrectinib in patients with advanced solid tumors, including ROS1 fusion-positive NSCLC. The primary efficacy end point in the phase 2 trial was confirmed objective response; efficacy analyses included patients from phase 1 and p

SUBMITTER: Drilon A 

PROVIDER: S-EPMC11702311 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature