Predicting RNA Structure and Dynamics with Deep Learning and Solution Scattering.

ABSTRACT: Advanced deep learning and statistical methods can predict structural models for RNA molecules. However, RNAs are flexible, and it remains difficult to describe their macromolecular conformations in solutions where varying conditions can induce conformational changes. Small-angle X-ray scattering (SAXS) in solution is an efficient technique to validate structural predictions by comparing the experimental SAXS profile with those calculated from predicted structures. There are two main challenges in comparing SAXS profiles to RNA structures: the absence of cations essential for stability and charge neutralization in predicted structures and the inadequacy of a single structure to represent RNA's conformational plasticity. We introduce Solution Conformation Predictor for RNA (SCOPER) to addre

SUBMITTER: Patt E 

PROVIDER: S-EPMC11702515 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature