Functional specialization of the subdomains of a bactofilin driving stalk morphogenesis in Asticcacaulis biprosthecum.

ABSTRACT: Bactofilins are a recently discovered class of cytoskeletal protein, widely implicated in subcellular organization and morphogenesis in bacteria and archaea. Several lines of evidence suggest that bactofilins polymerize into filaments using a central β-helical core domain, flanked by variable N- and C-terminal domains that may be important for scaffolding and other functions. However, a systematic exploration of the characteristics of these domains has yet to be performed. In Asticcacaulis biprosthecum, the bactofilin BacA serves as a topological organizer of stalk synthesis, localizing to the stalk base and coordinating the synthesis of these long, thin extensions of the cell envelope. The easily distinguishable phenotypes of wild-type A. biprosthecum stalks and ΔbacA "pseud

SUBMITTER: Jacq M 

PROVIDER: S-EPMC11702518 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature