Dynamic Changes in Gene Expression Through Aging in <i>Drosophila melanogaster</i> Heads.

ABSTRACT: Work in many systems has shown large-scale changes in gene expression during aging. However, many studies employ just two, arbitrarily-chosen timepoints at which to measure expression, and can only observe an increase or a decrease in expression between "young" and "old" animals, failing to capture any dynamic, non-linear changes that occur throughout the aging process. We used RNA sequencing to measure expression in male head tissue at 15 timepoints through the lifespan of an inbred Drosophila melanogaster strain. We detected >6,000 significant, age-related genes, nearly all of which have been seen in previous fly aging expression studies, and which include several known to harbor lifespan-altering mutations. We grouped our gene set into 28 clusters via their temporal expression ch

SUBMITTER: Hanson KM 

PROVIDER: S-EPMC11702523 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature