Specific <i>SOX10</i> enhancer elements modulate phenotype plasticity and drug resistance in melanoma.

ABSTRACT: Recent studies indicate that the development of drug resistance and increased invasiveness in melanoma is largely driven by transcriptional plasticity rather than canonical coding mutations. Understanding the mechanisms behind cell identity shifts in oncogenic transformation and cancer progression is crucial for advancing our understanding of melanoma and other aggressive cancers. While distinct melanoma phenotypic states have been well characterized, the processes and transcriptional controls that enable cells to shift between these states remain largely unknown. In this study, we initially leverage the well-established zebrafish melanoma model as a high-throughput system to dissect and analyze transcriptional control elements that are hijacked by melanoma. We identify key characteristics

SUBMITTER: DeGeorgia SN 

PROVIDER: S-EPMC11702536 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature