Of mice and men: Dendritic architecture differentiates human from mice neuronal networks.

ABSTRACT: The organizational principles that distinguish the human brain from other species have been a long-standing enigma in neuroscience. Focusing on the uniquely evolved human cortical layers 2 and 3, we computationally reconstruct the cortical architecture for mice and humans. We show that human pyramidal cells form highly complex networks, demonstrated by the increased number and simplex dimension compared to mice. This is surprising because human pyramidal cells are much sparser in the cortex. We show that the number and size of neurons fail to account for this increased network complexity, suggesting that another morphological property is a key determinant of network connectivity. Topological comparison of dendritic structure reveals much higher perisomatic (basal and oblique) branching den

SUBMITTER: Kanari L 

PROVIDER: S-EPMC11702562 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature