Yersinia pestis actively inhibits the production of extracellular vesicles by human neutrophils.

ABSTRACT: Yersinia pestis is the etiologic agent of the plague. A hallmark of plague is subversion of the host immune response by disrupting host signaling pathways required for inflammation. This non-inflammatory environment permits bacterial colonization and has been shown to be essential for disease manifestation. Previous work has shown that Y. pestis inhibits phagocytosis and degranulation by neutrophils. Manipulation of these key vesicular trafficking pathways suggests that Y. pestis influences EV secretion, cargo selection, trafficking, and/or maturation. Our goal was to define the EV population produced by neutrophils in response to Y. pestis and determine how these vesicles might influence inflammation. Toward these goals, EVs were isolated from human neutrophils

SUBMITTER: Sheneman KR 

PROVIDER: S-EPMC11702605 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature