PPARδ restrains the suppression function of intra-tumoral Tregs by limiting CIITA-MHC II expression.

ABSTRACT: Regulatory T cells (T_reg cells) play a critical role in suppressing anti-tumor immunity, often resulting in unfavorable clinical outcomes across numerous cancers. However, systemic T_reg depletion, while augmenting anti-tumor responses, also triggers detrimental autoimmune disorders. Thus, dissecting the mechanisms by which T_reg cells navigate and exert their functions within the tumor microenvironment (TME) is pivotal for devising innovative T_reg-centric cancer therapies. Our study highlights the role of peroxisome proliferator-activated receptor β/δ (PPARδ), a nuclear hormone receptor involved in fatty acid metabolism. Remarkably, PPARδ ablation in T_reg escalated tumor growth and augmented the immunosuppressive characteristics of the

SUBMITTER: Yang Q 

PROVIDER: S-EPMC11702609 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature