Tonic sound-evoked motility of cochlear outer hair cells in mice with impaired mechanotransduction.

ABSTRACT: Cochlear outer hair cells (OHCs) transduce sound-induced vibrations of their stereociliary bundles into receptor potentials that drive changes in cell length. While fast, phasic OHC length changes are thought to underlie an amplification process required for sensitive hearing, OHCs also exhibit large tonic length changes. The origins and functional significance of this tonic motility are unclear. Here, in vivo cochlear vibration measurements reveal tonic, sound-induced OHC motility in mice with stereociliary defects that impair mechanotransduction and eliminate cochlear amplification. Tonic motility in impaired mice was physiologically vulnerable but weakly related to any residual phasic motility, possibly suggesting a dissociation between the underlying mechanisms. Nevertheless, a

SUBMITTER: Dewey JB 

PROVIDER: S-EPMC11702648 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature