Tailoring rhodium-based metal-organic layers for parahydrogen-induced polarization: achieving 20% polarization of ¹H in liquid phase.

ABSTRACT: Heterogeneous catalysts for parahydrogen-induced polarization (HET-PHIP) would be useful for producing highly sensitive contrasting agents for magnetic resonance imaging (MRI) in the liquid phase, as they can be removed by simple filtration. Although homogeneous hydrogenation catalysts are highly efficient for PHIP, their sensitivity decreases when anchored on porous supports due to slow substrate diffusion to the active sites and rapid depolarization within the channels. To address this challenge, we explored 2D metal-organic layers (MOLs) as supports for active Rh complexes with diverse phosphine ligands and tunable hydrogenation activities, taking advantage of the accessible active sites and chemical adaptability of the MOLs. By adjusting the electronic properties of phosphines, TPP-MOL

SUBMITTER: Chen J 

PROVIDER: S-EPMC11702662 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature