Examining the role of Acinetobacter baumannii plasmid types in disseminating antimicrobial resistance.

ABSTRACT: Acinetobacter baumannii is a Gram-negative pathogen responsible for hospital-acquired infections with high levels of antimicrobial resistance (AMR). The spread of multidrug-resistant A. baumannii strains has become a global concern. Spread of AMR in A. baumannii is primarily mediated by the acquisition of AMR genes through mobile genetic elements, such as plasmids. Thus, a comprehensive understanding of the role of different plasmid types in disseminating AMR genes is essential. Here, we analysed the distribution of plasmid types, sampling sources, geographic locations, and AMR genes carried on A. baumannii plasmids. A collection of 813 complete plasmid entries was collated and analysed. We previously devised an Acinetobacter Plasmid Typing (APT) scheme where rep types were defined using 9

SUBMITTER: Lam MMC 

PROVIDER: S-EPMC11702686 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature