What makes human cortical pyramidal neurons functionally complex.

ABSTRACT: Humans exhibit unique cognitive abilities within the animal kingdom, but the neural mechanisms driving these advanced capabilities remain poorly understood. Human cortical neurons differ from those of other species, such as rodents, in both their morphological and physiological characteristics. Could the distinct properties of human cortical neurons help explain the superior cognitive capabilities of humans? Understanding this relationship requires a metric to quantify how neuronal properties contribute to the functional complexity of single neurons, yet no such standardized measure currently exists. Here, we propose the Functional Complexity Index (FCI), a generalized, deep learning-based framework to assess the input-output complexity of neurons. By comparing the FCI of cortical pyramida

SUBMITTER: Aizenbud I 

PROVIDER: S-EPMC11702691 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature