Predicting Future Development of Stress-Induced Anhedonia From Cortical Dynamics and Facial Expression.

ABSTRACT: The current state of mental health treatment for individuals diagnosed with major depressive disorder leaves billions of individuals with first-line therapies that are ineffective or burdened with undesirable side effects. One major obstacle is that distinct pathologies may currently be diagnosed as the same disease and prescribed the same treatments. The key to developing antidepressants with ubiquitous efficacy is to first identify a strategy to differentiate between heterogeneous conditions. Major depression is characterized by hallmark features such as anhedonia and a loss of motivation^1,2, and it has been recognized that even among inbred mice raised under identical housing conditions, we observe heterogeneity in their susceptibility and resilience to stress³. An

SUBMITTER: Coley AA 

PROVIDER: S-EPMC11702711 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature