Age at Menarche and Coronary Artery Disease Risk: Divergent Associations with Different Sources of Variation.

ABSTRACT:

Background

In women, both earlier and later age at menarche (AAM) are associated with increased risk of coronary artery disease (CAD). This study sought to determine if the relationship of AAM with CAD and CAD risk factors differs for different underlying sources of variation in AAM - specifically, variation attributable to common genetic variants as represented by a polygenic score (PGS) vs. variation in AAM adjusted for the PGS.

Methods

Primary analyses were conducted on data from 201,037 women in the UK Biobank and validation studies on data from 23,268 women in the Women's Genome Health Study (WGHS). For each individual, a PGS for AAM was calculated, then two variables were estimated from linear regression models: the genetically predicted AAM (the estimated AAM for each

SUBMITTER: Sonawalla A 

PROVIDER: S-EPMC11702712 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature