Prioritizing protein targets for dyslipidaemia and cardiovascular diseases using Mendelian randomization in South Asians.

ABSTRACT: South Asians are at higher risk of dyslipidaemia-a modifiable risk factor for cardiovascular diseases (CVDs). We aimed to identify protein targets for dyslipidaemia and CVDs in this population. We used a two-sample Mendelian randomization (MR) approach, supplemented with MR-Egger, weighted median, colocalization, and generalized MR (GMR), to evaluate the effect of 2,800 plasma proteins on high/low/non-high-density lipoprotein cholesterol (HDL-C/LDL-C/nonHDL-C), total cholesterol, and triglycerides. Observational analyses were conducted on MR findings with strong colocalization (posterior probability≥ 80%) and GMR findings. Univariate MR assessed lipid-associated proteins' effect on CVDs. Finally, we compared the potential causal effects of plasma proteins on lipids in South Asians with tho

SUBMITTER: Wu S 

PROVIDER: S-EPMC11702717 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature