Inflammatory reactivity is unrelated to childhood adversity or provoked modulation of nociception.

ABSTRACT: Adversity in childhood elevates the risk of persistent pain in adulthood. Neuroimmune interactions are a candidate mechanistic link between childhood adversity and persistent pain. We aimed to clarify whether immune reactivity is associated with provoked differences in nociceptive processing in adults with a range of childhood adversity. Pain-free adults (n=96; 61 female; median (range) age: 23 (18-65) years old) with a history of mild to severe childhood adversity underwent psychophysical assessments before and after in vivo neural provocation (high-frequency electrical stimulation) and, separately, before and after in vivo immune provocation (influenza vaccine administration). Psychophysical assessments included the surface area of secondary hyperalgesia after neural provoc

SUBMITTER: Bedwell GJ 

PROVIDER: S-EPMC11702747 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature