Evolutionary conservation of midline axon guidance activity between Drosophila and Tribolium Frazzled.

ABSTRACT: The regulation of midline crossing of axons is of fundamental importance for the proper development of nervous system connectivity in bilaterian animals. A number of conserved axon guidance signaling pathways coordinate to attract or repel axons at the nervous system midline to ensure the proper regulation of midline crossing. The attractive Netrin-Frazzled/DCC (Net-Fra) signaling pathway is widely conserved among bilaterians, but it is not clear whether the mechanisms by which Net and Fra promote midline crossing are also conserved. In Drosophila, Fra can promote midline crossing via Netrin-dependent and Netrin-independent mechanisms, by acting as a canonical midline attractive receptor and also through a non-canonical pathway to inhibit midline repulsion via transcriptional regula

SUBMITTER: Ghosh P 

PROVIDER: S-EPMC11702761 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature