Chromatin accessibility and gene expression in the parasite Trichomonas vaginalis.

ABSTRACT: Trichomonas vaginalis, the most common non-viral sexually transmitted parasite, causes more than 270 million infections annually. The infection's outcome varies greatly depending on different factors that include variation in human immune responses, the vaginal microbiome, and the inherent virulence of the strain. Although the pathogenicity of the different strains depends, at least partially, on differential gene expression of virulence genes; the regulatory mechanisms governing this transcriptional control remain incompletely understood. While many studies have reported a positive correlation between gene expression and chromatin accessibility in other cells, this relationship has not been analyzed in T. vaginalis. To address these questions, we selected two contrasting

SUBMITTER: Prat A 

PROVIDER: S-EPMC11702783 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature