Loss of H3K9 trimethylation leads to premature aging.

ABSTRACT: Aging is the major risk factor for most human diseases and represents a major socioeconomical challenge for modern societies. Despite its importance, the process of aging remains poorly understood. Epigenetic dysregulation has been proposed as a key driver of the aging process. Alterations in transcriptional networks and chromatin structure might be central to age-related functional decline. A prevalent feature described during aging is the overall reduction in heterochromatin, specifically marked by the loss of the repressive histone modification, histone 3 lysine 9 trimethylation (H3K9me3). However, the role of H3K9me3 in aging, especially in mammals, remains unclear. Here we show using a novel mouse strain, "TKOc", carrying a triple knockout of three methyltransferases responsible for H

SUBMITTER: Mrabti C 

PROVIDER: S-EPMC11702797 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature