Blue Light Damages Retinal Ganglion Cells Via Endoplasmic Reticulum Stress and Autophagy in Chickens.

ABSTRACT:

Purpose

Because chickens have excellent light perception properties, this study focused on investigating whether monochromatic light can cause photodamage in chicken retinal ganglion cells (RGCs).

Methods

Post-hatching day chickens were exposed to four different light-emitting diode light environments for five weeks, respectively, monochromatic blue light (480 nm), green light (560 nm), red light (660 nm), or white light (6000 K). The mechanisms through which monochromatic light influences the structure of the chicken retina were analyzed by detecting the morphological structure of the retina, gene and protein expression levels, and the ultrastructure of the optic nerve.

Results

Blue light exposure for five weeks significantly impacted the thickness of the inner retic

SUBMITTER: Pan D 

PROVIDER: S-EPMC11702841 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature