Are <i>Escherichia coli</i> causing recurrent cystitis just ordinary uropathogenic <i>E. coli</i> (UPEC) strains?

ABSTRACT: Specific determinants associated with Uropathogenic Escherichia coli (UPEC) causing recurrent cystitis are still poorly characterized. Using strains from a previous clinical study (Vitale study, clinicaltrials.gov, identifier NCT02292160) the aims of this study were (i) to describe genomic and phenotypic traits associated with recurrence using a large collection of recurrent and paired sporadic UPEC isolates and (ii) to explore within-host genomic adaptation associated with recurrence using series of 2 to 5 sequential UPEC isolates. Whole genome comparative analyses between 24 recurrent cystitis isolates (RCIs) and 24 phylogenetically paired sporadic cystitis isolates (SCIs) suggested a lower prevalence of putative mobile genetic elements (MGE) in RCIs, such as plasmids and prophage

SUBMITTER: Vautrin N 

PROVIDER: S-EPMC11702935 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature